Your Inner Fish: a Journey into the 3.5-Billion-Year History of the Human Body

“We were not designed rationally, but are products of a convoluted history.”

“In a perfectly designed world —one with no history— we would not have to suffer everything from hemorrhoids to cancer.”

“In preparing for battle, I have found that planning is essential, but plans are useless. - Dwight D. Eisenhower”

“Take the entire 4.5-billion-year history of the earth and scale it down to a single year, with January 1 being the origin of the earth and midnight on December 31 being the present. Until June, the only organisms were single-celled microbes, such as algae, bacteria, and amoebae. The first animal with a head did not appear until October. The first human appears on December 31. We, like all the animals and plants that have ever lived, are recent crashers at the party of life on earth.”

“[T]he unknown should not be a source of suspicion, fear, or retreat to superstition, but motivation to continue asking questions and seeking answers.”

“Over 99 percent of all species that ever lived are now extinct.”

“But why live in these environments at all? What possessed fish to get out of the water or live in the margins? Think of this: virtually every fish swimming in these 375-million-year-old streams was a predator of some kind. Some were up to sixteen feet long, almost twice the size of the largest Tiktaalik. The most common fish species we find alongside Tiktaalik is seven feet long and has a head as wide as a basketball. The teeth are barbs the size of railroad spikes. Would you want to swim in these ancient streams?”

“We would never have scales, feathers, or breasts if we didn't have teeth in the first place.”

“When you see these deep similarities among different organs and bodies, you begin to recognize that the diverse inhabitants of our world are just variations on a theme.”

“The immediate thing that strikes you when you see the inside of the hand is its compactness. The ball of your thumb, the thenar eminence, contains four different muscles. Twiddle your thumb and tilt your hand: ten different muscles and at least six different bones work in unison. Inside the wrist are at least eight small bones bones that move against one another. Bend your wrist, and you are using a number of muscles that begin in your forearm, extending into tendons as they travel down your arm to end at your hand. Even the simplest motion involves a complex interplay among many parts packed in a small space.”

“No sane paleontologist would ever claim that he or she had discovered "The Ancestor." Think about it this way: What is the chance that while walking through any random cemetery on our planet I would discover an actual ancestor of mine? Diminishingly small. What I would discover is that all people buried in these cemeteries-- no mater whether that cemetery is in China, Botswana, or Italy-- are related to me to different degrees. I can find this out by looking at their DNA with many of the forensic techniques in use in crime labs today. I'd see that some of the denizens of the cemeteries are distantly related to me, others are related more closely. This tree would be a very powerful window into my past and my family history. It would also have a practical application because I could use this tree to understand my predilection to get certain diseases and other facts of my biology. The same is true when we infer relationship among species.”

“What is it about a hand that seems quintessentially human? The answer must, at some level, be that the hand is a visible connection between us; it is a signature for who we are and what we can attain. Our ability to grasp, to build, and to make our thoughts real lies inside this complex of bones, nerves, and vessels.”

“كل صخرة على وجه الأرض لها قصة،قصة ما كان عليه العالم في حين كانت تلك الصخرة تتشكل،وداخل الصخرة هناك دليل على المناخات،والعوامل المحيطة الغابرة،التي عادة ما تكون مختلفة إلى حد كبير عما هي اليوم.أحيانا يكون الانفصال بين الحاضر والماضي أكثر حدة.”

“My building was constructed in 1896, and the utilities reflect an odd design that has been jerry-rigged further with each renovation. If you want to understand the wiring and plumbing in my building, you have to understand its history, how it was renovated for each new generation of scientists. My head has a long history also, and that history explains complicated nerves like the trigeminal and the facial.”

“هل تعني حقائق تاريخنا القديم أن الإنسان ليس خاصًا أو متفردًا بين المخلوقات الحية؟ طبعًا لا. في الحقيقة، إن معرفة شيء حول الأصول السّحيقة للإنسانية فقط تضيف لحقيقة وجودنا المتميّز: أن قدراتنا الخارقة جميعها، نشأت من مكونات أساسية تطوّرت في الأسماك، والمخلوقات الأخرى القديمة. من الأجزاء المشتركة جاء عالمٌ فريدٌ، فنحن جزءٌ منه حتى العَظْم،... وحتى في جيناتنا”

“عندما تنظر في العيون- انس الرومانسية -والخلق، نافذة الروح.مع جزيئاتها، جيناتها وأنسجتها المشتقّة من الميكروبات، قناديل البحر، فسوف ترى مجموعة كاملة من الوحـوش.”

“At conception, we start as a single cell that contains all the DNA needed to build our body. The plan for that entire body unfolds via the instructions contained in this single microscopic cell. To go from this generalized egg cell to a complete human, with trillions of specialized cells organized in just the right way, whole batteries of genes need to be turned on and off at just the right stages of development. Like a concerto composed of individual notes played by many instruments, our bodies are a composition of individual genes turning on and off inside each cell during our development.”

“Every limbed animal has the Sonic hedgehog gene.”

“They took an alga that is normally single-celled and let it live in the lab for over a thousand generations. Then they introduced a predator: a single-celled creature with a flagellum that engulfs other microbes to ingest them. In less than two hundred generations, the alga responded by becoming a clump of hundreds of cells; over time, the number of cells dropped until there were only eight in each clump. Eight turned out to be the optimum because it made clumps large enough to avoid being eaten but small enough so that each cell could pick up light to survive. The most surprising thing happened when the predator was removed: the algae continued to reproduce and form individuals with eight cells. In short, a simple version of a multicellular form had arisen from a no-body. If an experiment can produce a simple body-like organization from a no-body in several years, imagine what could happen in billions of years.”

“Some people can detect the odor molecules in a green bell pepper at a concentration of less than one part per trillion. That is like picking out one grain of sand from a mile-long beach.”

“Tiktaalik has a shoulder, elbow, and wrist composed of the same bones as an upper arm, forearm, and wrist in a human. When we study the structure of these joints to assess how one bonemoves against another, we see that Tiktaalik was specialized for a rather extraordinary function: it was capable of doing push-ups.”

“Don’t even bother trying to compare your body plan with a sponge. You could try, but the mere fact that you were trying would reveal something more psychiatric than anatomical.”

“قد نكون أكثر تعقيدًا الآن مما كنا عليه بعد واحد وعشرين يومًا من الإخصاب، ولكننا ما نزال أنبوبًا داخل آخر، وجميعُ أعضائنا مشتقّةٌ من واحدةٍ من الطبقات النسيجيّة الثلاث (germ layers) التي ظهرت في أسبوعنا الثاني بعد الإخصاب”

“knowing something about the deep origins of humanity only adds to the remarkable fact of our existence: all of our extraordinary capabilities arose from basic components that evolved in ancient fish and other creatures.”

“When the finely tuned balance among the different parts of bodies breaks down, the individual creature can die. A cancerous tumor, for example, is born when one batch of cells no longer cooperates with others. By dividing endlessly, or by failing to die properly, these cells can destroy the necessary balance that makes a living individual person. Cancers break the rules that allow cells to cooperate with one another. Like bullies who break cooperative societies, cancers behave in their own best interest until they kill their larger community, the human body.”

“The molecules that allow microbes to catch their prey and hold on to them are likely candidates for the molecules that form the rivet attachments between cells in our bodies.”

“The longest uninterrupted hiccups in a person lasted from 1922 to 1990.”

“The bones of the mammalian middle ear are like those of no other animal: mammals have three bones, whereas reptiles and amphibians have only one. Fish have none at all.”

“From studying the other primates that have color vision, we can estimate that our kind of color vision arose about 55 million years ago. At this time we find fossil evidence of changes in the composition of ancient forests. Before this time, the forests were rich in figs and palms, which are tasty but all of the same general color. Later forests had more of a diversity of plants, likely with different colors. It seems a good bet that the switch to color vision correlates with a switch from a monochromatic forest to one with a richer palette of colors in food.”

“In a sense, modified bits of ancient bacteria lie inside our retinas, helping us to see.”